Acetonitrile 99.9% HPLC Grade

Acetonitrile 99.9% HPLC Grade

Acetonitrile is an aliphatic nitrile with a pleasant odor and colorless liquid appearance when stored at room temperature. It is ideal for fluorimetric and spectrophotometric techniques due to its clarity under UV-visible light. It has been widely used as a polar aprotic solvent in organic syntheses due to its high eluting ability. Our premium quality Acetonitrile HPLC grade is highly recommended for high performance liquid chromatography (HPLC) systems. It is also certified by the ACS (American Chemical Society) as a reagent due to its high purity.

Acetonitrile 99.9% HPLC Grade (CAS 75-05-8, formula CH3CN) is a clear, colorless liquid with an ethereal odor and no suspended matter. It’s an aliphatic nitrile that mixes fully with water, and its density is 0.786 g/mL at 25 °C. The assay is a minimum of 99.9%. Listed limits include water at a maximum of 0.02%, residue after evaporation at a maximum of 0.005%, and UV absorption at 200 nm at a maximum of 0.05 AU. That last one matters when you run UV detection. You can download the Safety Data Sheet, Technical Data Sheet, Allergen Statement, BPA Statement, PFAS/PFOS Free Statement, TSE/BSE Declaration, Manufacturing Process Flow Chart and Certificates of Analysis from the page.

Most people pick this grade for HPLC work, fluorimetric and spectrophotometric methods, and as a polar aprotic solvent in organic synthesis. The problem is simple. A solvent with the wrong impurities or no paperwork can throw off your results and stall a batch. The documents sit right on the page, so you can check them before you order. Pick a 4L bottle or a 4 x 4L case. Want it on repeat? Set up Autoship. Need more volume? Request a quote and we’ll size it for you. It ships as hazmat and we handle that part for you, so your lab stays on budget, on time, every time.

Common Uses and Applications

HPLC solvent and mobile phase work

Spectrophotometric techniques

Polar aprotic solvent for organic synthesis

General laboratory reagent

Pharmaceuticals & Nutraceuticals

Q: What is Acetonitrile 99.9% HPLC Grade used for? A: It’s used in HPLC systems, in fluorimetric and spectrophotometric techniques, and as a polar aprotic solvent in organic synthesis. Research labs also use it as a general reagent.

Q: What does HPLC Grade mean, and is it suitable for HPLC work? A: HPLC Grade means the solvent is made for liquid chromatography, with tight limits on things that interfere with detection. This one has a minimum assay of 99.9%, water at a maximum of 0.02% and UV absorption at 210 nm at a maximum of 0.04 AU. The listing recommends it for HPLC systems.

Q: What sizes are available, and does it ship as hazmat? A: You can order a 4L bottle (CANHPLC-4L) or a 4 x 4L case (CANHPLC-4LCS). The Safety and Shipping tab reads: “UN 1648, 3, PKG II, Acetonitrile HPLC is hazardous. Hazmat fee required.”

Q: How do I get the SDS and Certificate of Analysis? A: Open the Product Manuals section on the page for the Safety Data Sheet and Technical Data Sheet. Certificates of Analysis are listed by certificate number under their own tab. If you can’t find what you need, contact us and we’ll send it.

Q: How should it be stored? A: Our guide on how to store acetonitrile walks through it. For handling details specific to this product, check the Safety Data Sheet.

Q: What purity and key limits does it have? A: The assay is a minimum of 99.9%. Listed limits include water at a maximum of 0.02%, residue after evaporation at a maximum of 0.005%, and UV absorption at 220 nm at a maximum of 0.02 AU.

Q: Does it come with PFAS and BPA statements? A: The Product Manuals list a PFAS/PFOS Free Statement and a BPA Statement, along with an Allergen Statement and a TSE/BSE Declaration. Open them for the exact wording.

Q: Where can I see other acetonitrile products? A: Browse the Acetonitrile category for everything we list.

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